Discovery of protein-DNA interactions by penalized multivariate regression
نویسندگان
چکیده
منابع مشابه
Discovery of protein–DNA interactions by penalized multivariate regression
Discovering which regulatory proteins, especially transcription factors (TFs), are active under certain experimental conditions and identifying the corresponding binding motifs is essential for understanding the regulatory circuits that control cellular programs. The experimental methods used for this purpose are laborious. Computational methods have been proven extremely effective in identifyi...
متن کاملMultivariate interactions in regression
A “multivariate interaction” in a regression model is a product of two independent variates (linear functions of the regressors) that is an additive component of the regression function E(Y |X). In many cases a substantial portion of the overall pairwise interaction structure in a regression function can be captured by a single multivariate interaction. Due to its parsimonious form, a multivari...
متن کاملPenalized logistic regression for detecting gene interactions.
We propose using a variant of logistic regression (LR) with (L)_(2)-regularization to fit gene-gene and gene-environment interaction models. Studies have shown that many common diseases are influenced by interaction of certain genes. LR models with quadratic penalization not only correctly characterizes the influential genes along with their interaction structures but also yields additional ben...
متن کاملPenalized Estimators in Cox Regression Model
The proportional hazard Cox regression models play a key role in analyzing censored survival data. We use penalized methods in high dimensional scenarios to achieve more efficient models. This article reviews the penalized Cox regression for some frequently used penalty functions. Analysis of medical data namely ”mgus2” confirms the penalized Cox regression performs better than the cox regressi...
متن کاملDetermination of Protein and Moisture in Fishmeal by Near-Infrared Reflectance Spectroscopy and Multivariate Regression Based on Partial Least Squares
The potential of Near Infrared Reflectance Spectroscopy (NIRS) as a fast method to predict the Crude Protein (CP) and Moisture (M) content in fishmeal by scanning spectra between 1000 and 2500 nm using multivariate regression technique based on Partial Least Squares (PLS) was evaluated. The coefficient of determination in calibration (R2C) and Standard Error of Calibra...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2009
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkp554